NEUROPEPTIDE-Y DOES NOT ALTER NMDA CONDUCTANCES IN CA3 PYRAMIDAL NEURONS - A SLICE-PATCH STUDY

被引：28

作者：

MCQUISTON, AR ^{[1
]}

COLMERS, WF ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PHARMACOL,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 02期

关键词：

SIGMA-RECEPTOR; PHENCYCLIDINE RECEPTOR; WHOLE-CELL VOLTAGE CLAMP; NEUROMODULATION; PRESYNAPTIC INHIBITION;

D O I：

10.1016/0304-3940(92)90929-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropeptide Y (NPY) has been reported to inhibit excitatory neurotransmission in hippocampus presynaptically. Recently, it has been suggested that NPY also potentiates N-methyl-D-aspartate (NMDA)-mediated excitatory responses in hippocampus, by action at a sigma or phencyclidine (PCP) binding site. We tested this hypothesis by examining the action of NPY on CA3 pyramidal cells using slice-patch voltage clamp recordings. NPY did not affect inward currents elicited by iontophoresis of NMDA onto the proximal dendrites of these cells under two different conditions, but did reduce the excitatory postsynaptic currents elicited by mossy fiber stimulation. NPY therefore does not appear to directly alter the postsynaptic NMDA response in CA3 cells.

引用

页码：261 / 264

页数：4