PROTECTIVE ACTIVITY OF THE LIPID-A ANALOG GLA-60 AGAINST MURINE CYTOMEGALOVIRUS-INFECTION IN IMMUNODEFICIENT MICE

被引：6

作者：

IKEDA, S

NEYTS, J

MATSUURA, M

KISO, M

HASEGAWA, A

NISHIMURA, C

DECLERCQ, E

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,TOKYO 108,JAPAN

[2] JICHI MED SCH,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[3] GIFU UNIV,FAC AGR,GIFU 50111,JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-7-1399

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The immunomodulating and murine cytomegalovirus (MCMV)-inhibiting effects of the synthetic lipid A subunit analogue GLA-60 were investigated in different strains of immunodeficient mice. Peritoneal natural killer (NK) cells obtained from nude (nu/nu) C57BL/6 mice or normal NMRI mice, which had been treated intraperitoneally with 10 mug of GLA-60 1 day earlier, exhibited a greater cytolytic activity than those from untreated mice. GLA-60 also stimulated NK cell activity in SCID (severe combined immune deficiency) mice (which are T and B cell-defective), but not in NK cell-defective beige (C57BL/6 bg/bg) mice. GLA-60 also enhanced the phagocytic activity of peritoneal macrophages in beige, nude and NMRI mice, but not in SCID mice. GLA-60, when administered as a single 150 mug dose 1 day before infection, completely protected beige mice against MCMV-associated mortality. It also caused a significant increase in the life-span of MCMV-infected nude and SCID mice.

引用

页码：1399 / 1403

页数：5

共 34 条

[1] PROTECTIVE EFFECT OF EARLY SERUM FROM MICE AFTER CYTOMEGALOVIRUS-INFECTION [J].