INFLUENCE OF THERAPY WITH RECOMBINANT ERYTHROPOIETIN ON SERUM LEVELS OF NEOPTERIN IN HEMODIALYZED SUBJECTS

被引：14

作者：

BUEMI, M ^{[1
]}

ALLEGRA, A ^{[1
]}

ALOISI, C ^{[1
]}

FRISINA, N ^{[1
]}

机构：

[1] UNIV MESSINA, INST INTERNAL MED, CHAIR MED PATHOL 1, I-98100 MESSINA, ITALY

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1991年 / 11卷 / 04期

关键词：

ERYTHROPOIETIN; NEOPTERIN; IMMUNE SYSTEM;

D O I：

10.1159/000168322

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The authors wished to investigate some aspects of the cell-mediated immunity in hemodialyzed subjects undergoing a treatment with recombinant erythropoietin (rHuEPO). The study was carried out through the dosage of the serum levels of neopterin, a substance produced by the macrophages and usable as a marker of their state of activation. The results show a significant reduction of the serum levels of pteridine already at the second month of treatment with rHuEPO (61 +/- 9 vs. 95 +/- 12 nmol/l), thus proving a probable inhibitory action carried out by erythropoietin on certain cells of the immune system.

引用

页码：281 / 283

页数：3

共 14 条

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