EXPRESSION OF THE HOMEOBOX HOX-4 GENES AND THE SPECIFICATION OF POSITION IN CHICK WING DEVELOPMENT

被引：365
作者：
IZPISUABELMONTE, JC
TICKLE, C
DOLLE, P
WOLPERT, L
DUBOULE, D
机构：
[1] EUROPEAN MOLEC BIOL LAB,MEYERHOFSTR 1,POSTFACH 102209,W-6900 HEIDELBERG 1,GERMANY
[2] UNIV COLL & MIDDLESEX SCH MED,DEPT ANAT & DEV BIOL,LONDON W1P 6DP,ENGLAND
来源：
NATURE | 1991年 / 350卷 / 6319期
关键词：
D O I：
10.1038/350585a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.
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页码：585 / 589
页数：5
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