DOPAMINERGIC MODULATION OF ADENYLATE-CYCLASE STIMULATION BY VASOACTIVE INTESTINAL PEPTIDE IN ANTERIOR-PITUITARY

被引：163

作者：

ONALI, P ^{[1
]}

SCHWARTZ, JP ^{[1
]}

COSTA, E ^{[1
]}

机构：

[1] ST ELIZABETHS HOSP, NIMH, PRECLIN PHARMACOL LAB, WASHINGTON, DC 20032 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1981年 / 78卷 / 10期

关键词：

D O I：

10.1073/pnas.78.10.6531

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing) by vasoactive intestinal peptide (VIP) was used as a model to investigate the molecular mechanisms triggered by the occupancy of dopamine recognition sites in rat anterior pituitary. Dopamine failed to change the basal enzyme activity, but it inhibited the stimulation of adenylate cyclase elicited by VIP. Apomorphine, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene and 2-bromo-.alpha.-ergocryptine mimicked the effect of dopamine, whereas (.sbd.)-sulpiride and classical neuroleptics antagonized it. Dopamine failed to modulate the activation of pituitary adenylate cyclase by prostaglandin E1, which does not increase prolactin secretion. Stimulation of D-2 (dopamine) receptors may affect pituitary secretion by inhibiting the activation of anterior pituitary adenylate cyclase by VIP or other secretagogues.

引用

页码：6531 / 6534

页数：4

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