IDENTIFICATION OF A MANNOSE-ACETATE-SPECIFIC 87-KDA RECEPTOR RESPONSIBLE FOR HUMAN NK AND LAK ACTIVITY

被引：16

作者：

HAUER, J ^{[1
]}

VOETSCH, W ^{[1
]}

ANDERER, FA ^{[1
]}

机构：

[1] MAX PLANCK GESELL, FRIEDRICH MIESCHER LAB, D-72076 TUBINGEN, GERMANY

来源：

IMMUNOLOGY LETTERS | 1994年 / 42卷 / 1-2期

关键词：

HUMAN NK AND LAK CYTOTOXICITY; NK CELL RECEPTOR; LACTOFERRIN SEQUENCE HOMOLOGY; ACETYLATED MANNOSE;

D O I：

10.1016/0165-2478(94)90027-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Target cell recognition and cytotoxicity of human CD56(+)NK and LAK cells is readily inhibited by acetylated mannose. Two respective NK cell receptor;candidates were isolated from human leukocyte lysates by mannose acetate affinity chromatography. The 87-kDa receptor showed sequence homologies with lactoferrin and the 59-kDa receptor represented a complex of two Ca-binding proteins MRP-8 and MRP-14 reportedly expressed only by cells of myeloid origin. The 87-kDa receptor exhibited heterogeneity in isoelectric focusing and behaved entirely differently from lactoferrin. Preincubation of tumor target cells with the 87-kDa receptor inhibited competitively target cell recognition and cytotoxicity of human CD56(+)NK and LAK cells.

引用

页码：7 / 12

页数：6

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