MOLECULAR-CLONING AND CHARACTERIZATION OF THE HUMAN E-CADHERIN CDNA

被引：144
作者：
BUSSEMAKERS, MJG
VANBOKHOVEN, A
MEES, SGM
KEMLER, R
SCHALKEN, JA
机构：
[1] UNIV HOSP NIJMEGEN,UROL RES LAB,POB 9101,6500 HB NIJMEGEN,NETHERLANDS
[2] MAX PLANCK INST IMMUNBIOL,FG MOLEK EMBRYOL,W-7800 FREIBURG,GERMANY
来源：
MOLECULAR BIOLOGY REPORTS | 1993年 / 17卷 / 02期
关键词：
CDNA CLONING; E-CADHERIN; HUMAN; INVASION SUPPRESSOR GENE; SEQUENCE ANALYSIS;
D O I：
10.1007/BF00996219
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
E-cadherin is a Ca2+-dependent cell adhesion molecule involved in cell-cell interaction. In its normal physiological function it plays an important role in embryonic development and tissue morphogenesis. Recent studies have shown that in cancer development E-cadherin can act as a suppressor of invasion. Indeed, in several kinds of carcinomas allelic loss of the E-cadherin/Uvomorulin locus and decreased E-cadherin expression have been described. The importance of E-cadherin in human cancer development may be substantiated by molecular analysis of the E-cadherin transcript. Therefore, we isolated and characterized the human E-cadherin cDNA. Comparison of the nucleotide and deduced amino acid sequences revealed that the human E-cadherin is highly homologous to the mouse E-cadherin (uvomorulin) and to other members of the cadherin family.
引用
收藏
页码：123 / 128
页数：6
相关论文
共 28 条
[1]   DISSECTING TUMOR-CELL INVASION - EPITHELIAL-CELLS ACQUIRE INVASIVE PROPERTIES AFTER THE LOSS OF UVOMORULIN-MEDIATED CELL CELL-ADHESION [J].
BEHRENS, J ;
MAREEL, MM ;
VANROY, FM ;
BIRCHMEIER, W .
JOURNAL OF CELL BIOLOGY, 1989, 108 (06) :2435-2447
[2]   DELETION MAPPING OF CHROMOSOME-8, CHROMOSOME-10, AND CHROMOSOME-16 IN HUMAN PROSTATIC-CARCINOMA [J].
BERGERHEIM, USR ;
KUNIMI, K ;
COLLINS, VP ;
EKMAN, P .
GENES CHROMOSOMES & CANCER, 1991, 3 (03) :215-220
[3]  
BUSSEMAKERS MJG, 1992, CANCER RES, V52, P2916
[4]   ALLELIC LOSS OF CHROMOSOME-16Q AND CHROMOSOME-10Q IN HUMAN PROSTATE-CANCER [J].
CARTER, BS ;
EWING, CM ;
WARD, WS ;
TREIGER, BF ;
AALDERS, TW ;
SCHALKEN, JA ;
EPSTEIN, JI ;
ISAACS, WB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8751-8755
[5]   A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].
DEVEREUX, J ;
HAEBERLI, P ;
SMITHIES, O .
NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395
[6]   CELL-ADHESION MOLECULES - IMPLICATIONS FOR A MOLECULAR HISTOLOGY [J].
EDELMAN, GM ;
CROSSIN, KL .
ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :155-190
[7]   MORPHOREGULATORY MOLECULES [J].
EDELMAN, GM .
BIOCHEMISTRY, 1988, 27 (10) :3533-3543
[8]   E-CADHERIN-MEDIATED CELL CELL-ADHESION PREVENTS INVASIVENESS OF HUMAN CARCINOMA-CELLS [J].
FRIXEN, UH ;
BEHRENS, J ;
SACHS, M ;
EBERLE, G ;
VOSS, B ;
WARDA, A ;
LOCHNER, D ;
BIRCHMEIER, W .
JOURNAL OF CELL BIOLOGY, 1991, 113 (01) :173-185
[9]   SEQUENCE-ANALYSIS OF A CDNA CLONE ENCODING THE LIVER-CELL ADHESION MOLECULE, L-CAM [J].
GALLIN, WJ ;
SORKIN, BC ;
EDELMAN, GM ;
CUNNINGHAM, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :2808-2812
[10]   UNSTABLE EXPRESSION OF E-CADHERIN ADHESION MOLECULES IN METASTATIC OVARIAN TUMOR-CELLS [J].
HASHIMOTO, M ;
NIWA, O ;
NITTA, Y ;
TAKEICHI, M ;
YOKORO, K .
JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (05) :459-463
123