PHARMACOKINETICS OF FAZADINIUM IN PATIENTS WITH RENAL-FAILURE

被引：17

作者：

DUVALDESTIN, P ^{[1
]}

BERTRAND, JC ^{[1
]}

CONCINA, D ^{[1
]}

HENZEL, D ^{[1
]}

LARENG, L ^{[1
]}

DESMONTS, JM ^{[1
]}

机构：

[1] HOP PURPAN,DEPT ANAESTHESIA,F-31052 TOULOUSE,FRANCE

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1979年 / 51卷 / 10期

关键词：

D O I：

10.1093/bja/51.10.943

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The serum concentrations of fazadinium and its metabolites were measured in 14 surgical patients with end-stage renal failure and in 11 patients free from kidney disease undergoing abdominal surgery. A two-compartment open model was used in the pharmacokinetic analysis of the data. The elimination half-life (T2-Janβ) was prolonged by 60% in patients with renal failure (from 85 to 140 min) and corresponded to a 30% decrease of the plasma clearance. The plasma concentration of the metabolites never exceeded 7% of the unchanged fazadinium. These results suggest that the duration of action will be less prolonged for fazadinium than for other non-depolarizing neuromuscular blocking drugs in patients with renal failure. A supplementary biliary pathway appears to be a possible explanation for the rapid elimination of fazadinium, even in patients with renal failure. © 1979 Macmillan Journals Ltd.

引用

页码：943 / 947

页数：5

共 11 条

[1] RELATIONSHIP OF SERUM CONCENTRATION OF PANCURONIUM TO ITS NEUROMUSCULAR ACTIVITY IN MAN [J].