We reviewed the histopathological findings in 1000 consecutive lymph node biopsy specimens obtained from both Saudi and non-Saudi patients. Mean patient age was 33.4±17.03 years, with a male to female ratio of 3:1. Analysis of the data indicated the following histopathological findings: 37%, reactive; 30%, granulomatous lymphadenitis; 14.3%, metastatic neoplasm; 8.7, non-Hodgkin's lymphoma; and 6.8%, Hodgkin's disease. The cervical lymph nodes constituted the most common group (59.6%), whereas paraaortic lymph nodes were the least common site (2.2%).