COMPLETE GENETIC-CHARACTERIZATION AND ANALYSIS OF ISOLATION OF SIN-NOMBRE-VIRUS

被引:74
作者
CHIZHIKOV, VE
SPIROPOULOU, CF
MORZUNOV, SP
MONROE, MC
PETERS, CJ
NICHOL, ST
机构
[1] CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV VIRAL & RICKETTSIAL DIS, ATLANTA, GA 30333 USA
[2] RUSSIAN STATE RES CTR VIROL & BIOTECHNOL VECTOR, NOVOSIBIRSK 633159, RUSSIA
[3] EMORY UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, ATLANTA, GA 30322 USA
[4] UNIV NEVADA, DEPT MICROBIOL, RENO, NV 89557 USA
关键词
D O I
10.1128/JVI.69.12.8132-8136.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
This study reports completion of the genetic characterization of the entire genome of Sin Nombre (SN) virus (NMH10) detected in autopsy tissues from a patient who died of hantavirus pulmonary syndrome (HPS). The large (L) genome segment was found to be 6,562 nucleotides in length and encoded a putative L polymerase that was 2,153 amino acids in length. No evidence of segment reassortment with other well-characterized hantaviruses was obtained, The sequence of the entire S, M, and L genome segments of SN virus (strain NMR11) isolated from a mouse (trapped in the residence of the patient infected with SN virus [NMH10]) by passage two times in Peromyscus maniculatus and then by five passages in E6 Vero cells was determined and compared with that of the virus detected in autopsy tissues, Only 16 nucleotide differences were detected between the virus genomes, and none of these resulted in virus protein amino acid substitutions, Determination of the exact 5'- and 3'-terminal sequences of all genome segments of SN virus and representatives of other serologic groups in the Hantavirus genus, family Bunyaviridae, showed the existence of conserved nucleotide domains that may be involved in important regulatory mechanisms, such as RNA encapsidation, polymerase binding, and control of transcription and replication.
引用
收藏
页码:8132 / 8136
页数:5
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