TREATMENT OF METASTATIC PROSTATE CARCINOMA WITH RADIOLABELED ANTIBODY CC49

被引:0
作者
MEREDITH, RF
BUESCHEN, AJ
KHAZAELI, MB
PLOTT, WE
GRIZZLE, WE
WHEELER, RH
SCHLOM, J
RUSSELL, CD
LIU, TP
LOBUGLIO, AF
机构
[1] UNIV ALABAMA,DEPT UROL,BIRMINGHAM,AL
[2] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294
[3] UNIV ALABAMA,DEPT PATHOL,DIV RADIOL & NUCL MED,BIRMINGHAM,AL 35294
[4] NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892
关键词
PROSTATE CARCINOMA; RADIOLABELED ANTIBODY;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A Phase II trial of 75 mCi/m(2) I-131-anti-TAG-72 high-affinity antibody CC49 was studied in 15 patients with hormone-resistant metastatic prostate cancer. Methods: Patients had adequate renal, liver and hematopoietic function. No previous cytotoxic chemotherapy was allowed and previous radiation was limited to 20% of the active bone marrow. Results: No acute adverse reactions occurred, but all patients had evidence of an immune response to CC49 by 4 wk. Six of 10 symptomatic patients had bone pain relief, but no patients met the radiographic or PSA criteria for objective response. Positive imaging of bone and/or soft-tissue lesions was noted for 13 of the 15 patients. Conclusions: CC49 had a high frequency of tumor localization with evidence of anti-tumor effects (pain relief).
引用
收藏
页码:1017 / 1022
页数:6
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