Efficiency and safety analysis of Prospidinum in subepithelial haze prevention after photorefractive keratectomy

The aim of the investigation is to analyze the efficiency and safety of preventive intraoperative administration of Prospidinum to prevent subepithelial haze after photorefractive keratectomy. Materials and methods. The basic group consisted of 69 patients (118 eyes) with myopia from 1.5 to 10.0 diopter, mean age 25.0 +/- 7.5 years, who underwent photorefractive keratectomy with application of 2.5% Prospidinum solution on cornea after ablation. In the control group there were 70 patients (118 eyes) with myopia from 2.25 to 8.5 diopter operated earlier without Prospidinum application. To correct myopia Excimer laser MEL-70 G-Scan (Aesculap Meditec, Germany) was used in all cases. Results. Epithelialization periods were the same in both groups. The basic group (118 eyes) had none complications related to Prospidinum application. Early corneal haze was observed postoperatively in the basic group in 11.8% of cases, in the control group - in 24.5% of patients. 1.7% of patients in the basic group had late haze, and 6.7% - in the control group. 6.7% and 15.25% of patients respectively, had partial regress of refraction result. Mean noncorrected acuity of vision after the operation was 0.85 +/- 0.27 in the basic group, and 0.76 +/- 0.21 - in the control group. Conclusion. Prospidinum (2.5% solution) applied on photoablation zone for 30 s in photorefractive keratectomy statistically significantly reduces subepithelial haze rate.