SELEGILINE PROTECTS DOPAMINERGIC-NEURONS IN CULTURE FROM TOXIC FACTOR(S) PRESENT IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH PARKINSONS-DISEASE

被引：27

作者：

HAO, R

EBADI, M

PFEIFFER, RF

机构：

[1] UNIV TENNESSEE,COLL MED,DEPT NEUROL,MEMPHIS,TN 38163

[2] UNIV NEBRASKA,COLL MED,DEPT PHARMACOL,OMAHA,NE 68198

来源：

NEUROSCIENCE LETTERS | 1995年 / 200卷 / 02期

关键词：

DOPAMINERGIC NEURONS; DOPAMINE; MONOAMINE OXIDASE B; OXIDATIVE STRESS; SELEGILINE; NEUROTOXICITY; NEUROPROTECTION;

D O I：

10.1016/0304-3940(95)12113-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) contains substance(s) that inhibit the growth and functions of dopaminergic neurons, Furthermore, selegiline, a monoamine oxidase B (MAO) inhibitor (0.125-0.250 mu M) enhanced the number of tyrosine hydroxylase (TH)-positive neurons, augmented the high affinity uptake of dopamine (DA), and averted the neurotoxic effect s of CSF of PD patients on rat mesencephalic neurons in culture. The neuroprotective effects of selegiline may be related either to its ability to inhibit MAO B, preventing the generation of free radicals, or to neuronal rescue property due to unknown mechanisms.

引用

页码：77 / 80

页数：4

共 33 条

[1] L-DEPRENYL INCREASES GFAP IMMUNOREACTIVITY SELECTIVELY IN ACTIVATED ASTROCYTES IN RAT-BRAIN [J].