Correlation between Body Mass Index and CD4 Level in HIV Patients with Antiretroviral Therapy

The adverse consequence of overweight and obese condition in major population related to it's mortality and morbidity of specific diseases like coronary heart disease has been well known. However, in immunocompromised patients, in the context of body weight with it's morbidity and mortality needs further examination. The objective of this research was to find out the relationship between BMI and CD4 level, which describes disease progressivity from HIV patients whom already had antiretroviral (ARV) therapy. We conducted cross sectional method with descriptive analytic from secondary data of medical records from HIV patients who came to Teratai Polyclinic of Hasan Sadikin General Hospital Bandung from 2007 to 2011. From 936 HIV patients analyzed, median BMI was 19,4 with range between 12.1-36.2 kg/m(2), median CD4 was 151 cells/mm(3) with range between 1-1,329. The r value was 0.409, suggested positive correlation significance between BMI and CD4 value, CD4 value increased parallel with the increasing of BMI, with intermediate p value (p=0.0001). Since we categorized BMI, the median of CD4 between all categories (p=0.0001), range from the smallest to the highest was underweight:75 (1-1,329), normoweight: 229 (4-1,047), overweight: 259 (2-1,275), obese: 447 (71-654) cells/mm(3), respectively. As conclusion, increasing of BMI related to enhancement of CD4 level, suggests reduction of HIV morbidity and mortality.