THE P1 FAMILY - A NEW CLASS OF NUCLEAR MAMMALIAN PROTEINS RELATED TO THE YEAST MCM REPLICATION PROTEINS

被引：84
|
作者：
HU, B [1 ]
BURKHART, R [1 ]
SCHULTE, D [1 ]
MUSAHL, C [1 ]
KNIPPERS, R [1 ]
机构：
[1] UNIV KONSTANZ,DIV BIOL,D-78434 CONSTANCE,GERMANY
来源：
NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 23期
关键词：
D O I：
10.1093/nar/21.23.5289-a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Monospecific antibodies against an oligopeptide, conserved among the Mcm class of yeast replication proteins, were used to screen a human cDNA library. Eight of the isolated cDNA clones have the potential to code for sections of proteins with high sequence similarities to the yeast proteins Mcm3 and Cdc46 from Saccharomyces cerevisiae and Cdc21 from S. pombe. Our results establish a novel and highly conserved family of nuclear proteins in mammalian cells.
引用
收藏
页码：5289 / 5293
页数：5
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