INTERPHENYLENE 7-OXABICYCLO[2.2.1]HEPTANES - SQ-33961 - A NEW POTENT, LONG-ACTING THROMBOXANE ANTAGONIST

被引：9

作者：

MISRA, RN

BROWN, BR

SHER, PM

PATEL, MM

GOLDENBERG, HJ

MICHEL, IM

HARRIS, DN

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)81106-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and initial biological evaluation of a novel series of chiral interphenylene 7-oxabicyclo-[2.2.1]heptane TxA2 antagonists with 4-amido oxazole omega chains is described. Within this series SQ 33,961 has been identified as a highly potent TxA2 antagonist with an exceptionally long in vivo duration of action.

引用

页码：461 / 464

页数：4