INTERPHENYLENE 7-OXABICYCLO[2.2.1]HEPTANES - SQ-33961 - A NEW POTENT, LONG-ACTING THROMBOXANE ANTAGONIST

被引：9
作者：
MISRA, RN
BROWN, BR
SHER, PM
PATEL, MM
GOLDENBERG, HJ
MICHEL, IM
HARRIS, DN
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(01)81106-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and initial biological evaluation of a novel series of chiral interphenylene 7-oxabicyclo-[2.2.1]heptane TxA2 antagonists with 4-amido oxazole omega chains is described. Within this series SQ 33,961 has been identified as a highly potent TxA2 antagonist with an exceptionally long in vivo duration of action.
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页码：461 / 464
页数：4
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