DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38

被引：14

作者：

de Dieuleveult, Maud ^{[1
,2
,3
]}

Miotto, Benoit ^{[1
,2
,3
]}

机构：

[1] Inst Cochin, INSERM U1016, Batiment Fac Med,4eme Etage,4501, Paris, France

[2] CNRS UMR8104, Paris, France

[3] Univ Paris 05, Dept Dev Reprod & Canc, Sorbonne Paris Cite, Paris, France

来源：

EPIGENETICS INSIGHTS | 2018年 / 11卷

关键词：

DNA methylation; cancer; ZBTB38; gene expression; DNA replication;

D O I：

10.1177/2516865718811117

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation-sensitive transcription factors in mammalian cells.

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页数：5

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