DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38

被引：14

作者：

de Dieuleveult, Maud ^{[1
,2
,3
]}

Miotto, Benoit ^{[1
,2
,3
]}

机构：

[1] Inst Cochin, INSERM U1016, Batiment Fac Med,4eme Etage,4501, Paris, France

[2] CNRS UMR8104, Paris, France

[3] Univ Paris 05, Dept Dev Reprod & Canc, Sorbonne Paris Cite, Paris, France

来源：

EPIGENETICS INSIGHTS | 2018年 / 11卷

关键词：

DNA methylation; cancer; ZBTB38; gene expression; DNA replication;

D O I：

10.1177/2516865718811117

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation-sensitive transcription factors in mammalian cells.

引用

页数：5

共 31 条

[1] Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation [J].

Bartke, Till ;

Vermeulen, Michiel ;

Xhemalce, Blerta ;

Robson, Samuel C. ;

Mann, Matthias ;

Kouzarides, Tony .

CELL, 2010, 143 (03) :470-484

[2] Cullin E3 Ligase Activity Is Required for Myoblast Differentiation [J].

Blondelle, Jordan ;

Shapiro, Paige ;

Domenighetti, Andrea A. ;

Lange, Stephan .

JOURNAL OF MOLECULAR BIOLOGY, 2017, 429 (07) :1045-1066

[3] Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso [J].

Buck-Koehntop, Bethany A. ;

Stanfield, Robyn L. ;

Ekiert, Damian C. ;

Martinez-Yamout, Maria A. ;

Dyson, H. Jane ;

Wilson, Ian A. ;

Wright, Peter E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (38) :15229-15234

[4] Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System [J].

Buckley, Shannon M. ;

Aranda-Orgilles, Beatriz ;

Strikoudis, Alexandros ;

Apostolou, Effie ;

Loizou, Evangelia ;

Moran-Crusio, Kelly ;

Farnsworth, Charles L. ;

Koller, Antonius A. ;

Dasgupta, Ramanuj ;

Silva, Jeffrey C. ;

Stadtfeld, Matthias ;

Hochedlinger, Konrad ;

Chen, Emily I. ;

Aifantis, Iannis .

CELL STEM CELL, 2012, 11 (06) :783-798

[5] Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation [J].

Cheng, Jingdong ;

Yang, Huirong ;

Fang, Jian ;

Ma, Lixiang ;

Gong, Rui ;

Wang, Ping ;

Li, Ze ;

Xu, Yanhui .

NATURE COMMUNICATIONS, 2015, 6

[6] A family of human zinc finger proteins that bind methylated DNA and repress transcription [J].

Filion, GJP ;

Zhenilo, S ;

Salozhin, S ;

Yamada, D ;

Prokhortchouk, E ;

Defossez, PA .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (01) :169-181

[7] Targeting the cancer epigenome for therapy [J].

Jones, Peter A. ;

Issa, Jean-Pierre J. ;

Baylin, Stephen .

NATURE REVIEWS GENETICS, 2016, 17 (10) :630-641

[8] Functions of DNA methylation: islands, start sites, gene bodies and beyond [J].

Jones, Peter A. .

NATURE REVIEWS GENETICS, 2012, 13 (07) :484-492

[9]

Kasprzyk Laetitia, 2013, Biologie Aujourd hui, V207, P1, DOI 10.1051/jbio/2013001

[10] Genomic DNA methylation: the mark and its mediators [J].

Klose, RJ ;

Bird, AP .

TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (02) :89-97

← 1 2 3 4 →