MORPHINE-DOPAMINE INTERACTION - VENTRAL TEGMENTAL MORPHINE INCREASES NUCLEUS-ACCUMBENS DOPAMINE RELEASE

被引：198

作者：

LEONE, P ^{[1
]}

POCOCK, D ^{[1
]}

WISE, RA ^{[1
]}

机构：

[1] CONCORDIA UNIV, CTR STUDIES BEHAV NEUROBIOL, DEPT PSYCHOL, MONTREAL H3G 1M8, QUEBEC, CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 02期

关键词：

MORPHINE; VENTRAL TEGMENTAL AREA; DOPAMINE; NUCLEUS ACCUMBENS; OPIOIDS;

D O I：

10.1016/0091-3057(91)90210-S

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Microdialysis and high-performance liquid chromatography with electrochemical detection were used to determine extracellular levels of dopamine following ventral tegmental morphine injections into chloral hydrate-anesthetized rats. Morphine (13.2 nanomoles in 0.5-mu-l of Ringer's solution) caused 50-150% increases in nucleus accumbens dopamine and metabolites; latency for the effect was on the order of 15 min with peak effects occurring in 30-50 min. Contralateral dopamine levels were influenced only minimally. These data suggest opiate receptors in or near the ventral tegmental area as sites of the opioid action that is responsible for opiod activation of the mesolimbic dopamine system.

引用

页码：469 / 472

页数：4

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