THE SINGLE PSEUDOURIDINE RESIDUE IN ESCHERICHIA-COLI 16S RNA IS LOCATED AT POSITION-516

被引：57
作者：
BAKIN, A
KOWALAK, JA
MCCLOSKEY, JA
OFENGAND, J
机构：
[1] ROCHE INST MOLEC BIOL,ROCHE RES CTR,NUTLEY,NJ 07110
[2] UNIV UTAH,DEPT BIOCHEM,SALT LAKE CITY,UT 84112
[3] UNIV UTAH,DEPT MED CHEM,SALT LAKE CITY,UT 84112
来源：
NUCLEIC ACIDS RESEARCH | 1994年 / 22卷 / 18期
关键词：
D O I：
10.1093/nar/22.18.3681
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The number and location of pseudouridine residues in Escherichia coli 16S ribosomal RNA has been determined by a combination of direct and indirect methods. Only one residue was found, at position 516. This site is at the 5'-end of one of the three most highly conserved long sequences of this RNA molecule. A number of experimental findings have strongly implicated this loop in the fidelity of codon recognition by A-site bound tRNA. By virtue of its location, we suggest that Psi 516 may also play a role in maintaining the fidelity of protein synthesis.
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页码：3681 / 3684
页数：4
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