ROLE OF DETOXICATION PATHWAYS IN ACUTE TOXICITY LEVELS OF PHOSPHOROTHIONATE INSECTICIDES IN THE RAT

被引：76

作者：

CHAMBERS, JE ^{[1
]}

MA, TG ^{[1
]}

BOONE, JS ^{[1
]}

CHAMBERS, HW ^{[1
]}

机构：

[1] MISSISSIPPI STATE UNIV,COLL VET MED,DEPT ENTOMOL,MISSISSIPPI STATE,MS 39762

来源：

LIFE SCIENCES | 1994年 / 54卷 / 18期

关键词：

DETOXICATION; DEARYLATION; A-ESTERASE; ALIESTERASE; CARBOXYLESTERASE;

D O I：

10.1016/0024-3205(94)00515-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Phosphorothionate insecticides and their active oxon metabolites can be detoxified by a variety of hepatic mechanisms. Cytochrome P450-mediated dearylation activity was higher in males than in females. While dearylation was induced by phenobarbital in both sexes, it was induced by beta-naphthoflavone in females only. Detoxication of oxons in the presence of EDTA was inducible by phenobarbital, was higher in males than in females, and paralleled aliesterase activity. In vitro Ca++-dependent A-esterase-mediated hydrolysis of chlorpyrifos-oxon but not of paraoxon occurred at biologically relevant nM concentrations. This hydrolysis was also inducible by phenobarbital. Glutathione-mediated conjugation did not appear to be relevant to the disposition of the phosphorothionates studied here. Hepatic detoxication via dearylation, aliesterase phosphorylation and A-esterase-mediated hydrolysis (for some organophosphates) all appear to be relevant reactions in the attenuation of acute toxicity.

引用

页码：1357 / 1364

页数：8

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