DIORGANOTIN 2-FLUOROCINNAMATES AND 4-FLUOROPHENYLACETATES - SYNTHESIS, CHARACTERIZATION AND INVITRO ANTITUMOR-ACTIVITY

被引：77

作者：

GIELEN, M

ELKHLOUFI, A

BIESEMANS, M

KAYSER, F

WILLEM, R

机构：

[1] Free University of Brussels (VUB), Department of General and Organic Chemistry (AOSC), Brussels, B-1050

[2] Free University of Brussels (VUB), High Resolution NMR Centre

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1993年 / 7卷 / 03期

关键词：

ORGANOTIN; ANTITUMOR; FLUOROCINNAMATE; FLUOROPHENYLACETATE;

D O I：

10.1002/aoc.590070307

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis and characterization by spectroscopy of several new di-n-butyltin and diethyltin 2-fluorocinnamates and 4-fluorophenylacetates are described. In vitro tests on two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, showed that two of these compounds are more active than cisplatin. Other in vitro tests performed by the NCI, USA on a panel of human tumour cell lines show that one of them, bis[di-n-butyl(2-fluorophenylacetato)tin] oxide, is characterized by statistically significant D(GI50), D(TGI) and D(LC50) sensitivities, but non-significant D(H) and MGD(H) selectivities, whereas the analogous 2-fluorocinnamate shows no such significant values.

引用

页码：201 / 206

页数：6

共 12 条

[1] SYNTHESIS, CHARACTERIZATION AND INVITRO ANTITUMOR-ACTIVITY OF DIMETHYL-TIN(IV), DIETHYL-TIN(IV) AND DI-T-BUTYL-TIN(IV) DERIVATIVES OF SUBSTITUTED SALICYLIC ACIDS [J].