Therapeutic implications of autoantibodies in rheumatoid arthritis

被引：39

作者：

Aletaha, Daniel ^{[1
]}

Blueml, Stephan ^{[1
]}

机构：

[1] Med Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria

来源：

RMD OPEN | 2016年 / 2卷 / 01期

关键词：

D O I：

10.1136/rmdopen-2014-000009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies. Their value for diagnostic/prognostic purposes has been well established. In contrast, their role in established disease and their associations with disease activity is less clear. Moreover, as evidence is accumulating that these autoantibodies are causally involved in certain key aspects of the disease, such as the initiation and perpetuation of joint inflammation or join destruction, autoantibodies in RA can no longer be regarded as mere epiphenomena, but are integral elements of the pathophysiology of RA.

引用

页数：8

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