MYELOPEROXIDASE-MEDIATED ACTIVATION OF XENOBIOTICS BY HUMAN-LEUKOCYTES

被引：40

作者：

HOFSTRA, AH

UETRECHT, JP

机构：

[1] UNIV TORONTO,FAC PHARM,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,FAC MED,TORONTO M5S 1A1,ONTARIO,CANADA

[3] SUNNYBROOK MED CTR,TORONTO M4N 3M5,ONTARIO,CANADA

[4] UNIV TORONTO,CTR DRUG SAFETY RES,TORONTO M5S 1A1,ONTARIO,CANADA

[5] UNIV TORONTO,FAC PHARM,TORONTO M5S 2S2,ON,CANADA

来源：

TOXICOLOGY | 1993年 / 82卷 / 1-3期

关键词：

IDIOSYNCRATIC; IMMUNE-MEDIATED; MYELOPEROXIDASE; NEUTROPHILS; RESPIRATORY BURST;

D O I：

10.1016/0300-483X(93)90066-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peripheral blood leukocytes contain a variety of enzymes that are capable of metabolising xenobiotics. The enzyme myeloperoxidase (MPO) appears to be the most important for drug metabolism. MPO is a peroxidase/oxidase and generates the powerful oxidant hypochlorous acid. MPO- or MPO-generated oxidants are capable of oxidizing a wide variety of compounds and a broad range of functional groups, especially those that contain nitrogen and sulfur. Leukocytes have a role in immune response; therefore, reactive intermediates generated by leukocyte metabolism of xenobiotics may have a role in idiosyncratic drug reactions, particularly those that are immune-mediated such as drug-induced lupus or agranulocytosis.

引用

页码：221 / 242

页数：22

共 112 条

[1] METABOLISM OF BENZOIC-ACID BY STIMULATED POLYMORPHONUCLEAR CELLS [J].