HIGH-RESOLUTION LOCALIZATION OF 69 POTENTIAL HUMAN ZINC FINGER PROTEIN GENES - A NUMBER ARE CLUSTERED

被引：155
作者：
HOOVERS, JMN
MANNENS, M
JOHN, R
BLIEK, J
VANHEYNINGEN, V
PORTEOUS, DJ
LESCHOT, NJ
WESTERVELD, A
LITTLE, PFR
机构：
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOCHEM,LONDON SW7 2AZ,ENGLAND
[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
来源：
GENOMICS | 1992年 / 12卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0888-7543(92)90372-Y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the "link" sequence between contigous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or "candidate" genes for diseases associated with these chromosome regions. © 1992.
引用
收藏
页码：254 / 263
页数：10
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