INTRATHECAL VINCRISTINE - A FATAL CHEMOTHERAPEUTIC ERROR WITH DEVASTATING CENTRAL-NERVOUS-SYSTEM EFFECTS

被引:27
作者
BAIN, PG
LANTOS, PL
DJUROVIC, V
WEST, I
机构
[1] INST PSYCHIAT,DEPT NEUROPATHOL,LONDON SE5 8AF,ENGLAND
[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DIV FORENS MED,LONDON SE1 9RT,ENGLAND
关键词
INTRATHECAL VINCRISTINE; ASCENDING MYELOENCEPHALOPATHY; NEURONAL DAMAGE; NEUROFILAMENT ACCUMULATION;
D O I
10.1007/BF00314787
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The devastating neuropathological changes wrought by the intrathecal administration of vincristine are reported, with a detailed account of the widespread lesions in the brain and spinal cord, found in post-mortem light- and electron-microscope studies.
引用
收藏
页码:230 / 234
页数:5
相关论文
共 38 条
[1]  
APPLEBAUM F, 1985, CANCER, V55, P2202
[2]   STUDIES ON ANTIMITOTIC ACTIVITY OF LEUROCRISTINE (VINCRISTINE) [J].
CARDINALI, G ;
ENEIN, MA .
BLOOD, 1963, 21 (01) :102-+
[3]   VINCRISTINE NEUROPATHY - CLINICAL AND ELECTROPHYSIOLOGICAL OBSERVATIONS [J].
CASEY, EB ;
JELLIFE, AM ;
LEQUESNE, PM ;
MILLETT, YL .
BRAIN, 1973, 96 :69-86
[4]   THE MODE OF ACTION OF VINCA ALKALOIDS [J].
CSUKA, O ;
SUGAR, J ;
PALYI, I ;
SOMFAIRELLE, S .
ONCOLOGY, 1980, 37 :83-87
[5]  
DONOSO JA, 1979, CANCER RES, V39, P1604
[6]  
ELI L, 1986, ABPI DATA SHEET COMP, P811
[7]  
FREI E, 1964, CANCER RES, V24, P1918
[8]  
GAIDYS WG, 1983, CANCER, V52, P799, DOI 10.1002/1097-0142(19830901)52:5<799::AID-CNCR2820520508>3.0.CO
[9]  
2-Z
[10]  
GREEN DM, 1988, CANCER, V62, P270, DOI 10.1002/1097-0142(19880715)62:2<270::AID-CNCR2820620208>3.0.CO