GLUTAMATE-INDUCED INWARD CURRENT IN A CLONAL NEUROBLASTOMA CELL-LINE

被引：12
作者：
VANDERVALK, JBF
VIJVERBERG, HPM
机构：
[1] Research Institute of Toxicology, University of Utrecht, NL-3508 TD Utrecht
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 185卷 / 01期
关键词：
Excitatory amino acids; L-Glutamic acid; Neuroblastoma; Voltage clamp;
D O I：
10.1016/0014-2999(90)90215-R
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The presence of glutamate-induced electrophysiological responses was examined in eight clonal neuroblastoma cell lines with the whole-cell voltage clamp technique. Only N2A cells responded to glutamate superfusion with a concentration-dependent, reversible inward current. Superfusion with the analogues kainic acid, quisqualic acid and N-methyl-D-aspartic acid also evoked inward currents but they had a smaller amplitude. The results indicate that N2A neuroblastoma cells could serve as an in vitro model to study the functional properties of glutamate receptors and associated ion channels. © 1990.
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页码：99 / 102
页数：4
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