THE EFFECT OF STEROIDS ON THEOPHYLLINE ABSORPTION

被引:0
作者
TATSIS, G [1 ]
ORPHANIDOU, D [1 ]
DOURATSOS, D [1 ]
MELLISSINOS, C [1 ]
PANTELAKIS, D [1 ]
PIPINI, E [1 ]
JORDANOGLOU, J [1 ]
机构
[1] UNIV ATHENS,SOTIRIA HOSP,DEPT PULM,GR-10676 ATHENS,GREECE
关键词
THEOPHYLLINE; HYDROCORTISONE; CHRONIC ASTHMA; DRUG ABSORPTION;
D O I
10.1177/030006059101900405
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effect of hydrocortisone on plasma theophylline concentrations was evaluated in 20 patients suffering from chronic bronchitis or stable bronchial asthma. Choline theophyllinate (400 mg) was orally administered every 12 h for 8 days and blood samples were taken every 2 h during the day for the measurement of theophylline concentrations. Intravenous bolus injections of 500 or 1000 mg hydrocortisone on day 5 or day 7, respectively, did not significantly alter plasma theophylline concentrations.
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页码:326 / 329
页数:4
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