DIFFERENTIAL-EFFECTS OF BACLOFEN AND GAMMA-AMINOBUTYRIC-ACID (GABA) ON RAT PIRIFORM CORTEX PYRAMIDAL NEURONS INVITRO

被引：0

作者：

DOI, N

CARPENTER, DO

HORI, N

机构：

[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,ALBANY,NY 12201

[2] NEW YORK STATE DEPT HLTH,SCH PUBL HLTH,ALBANY,NY 12201

[3] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

[4] KYUSHU UNIV,FAC DENT,DEPT PHARMACOL,FUKUOKA 812,JAPAN

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1990年 / 10卷 / 04期

关键词：

GAMMA-AMINOBUTYRIC ACID (GABA); PIRIFORM CORTEX; GABA RECEPTORS; BRAIN SLICES;

D O I：

10.1007/BF00712849

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABA(A) and GABA(B) receptors, respectively. 3. The GABA(A) receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.

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页码：559 / 564

页数：6

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