INDUCTION OF PLASMA INHIBITORS OF INTERLEUKIN-1 AND TNF-ALPHA ACTIVITY BY ENDOTOXIN ADMINISTRATION TO NORMAL HUMANS

被引:53
作者
SPINAS, GA [1 ]
BLOESCH, D [1 ]
KAUFMANN, MT [1 ]
KELLER, U [1 ]
DAYER, JM [1 ]
机构
[1] UNIV GENEVA,HOP CANTONAL,DEPT MED,DIV IMMUNOL & ALLERGOL,CH-1211 GENEVA 4,SWITZERLAND
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1990年 / 259卷 / 05期
关键词
INTERLEUKIN-1-BETA; TUMOR NECROSIS FACTOR-ALPHA; FEVER; VOLUNTEERS;
D O I
10.1152/ajpregu.1990.259.5.R993
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Several naturally occurring inhibitors of interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) have been demonstrated both in serum and urine of febrile patients. These factors are considered to be part of a regulatory system counteracting potential deleterious effects of the cytokines. We have assayed plasma samples of volunteers who received a bolus intravenous injection of either 4 ng/kg body wt of Escherichia coli endotoxin (n = 6) or 0.9% saline (n = 4) for the presence of IL-1 and TNF-alpha inhibitory activity. Plasma obtained 3 h after endotoxin injection inhibited IL-1-induced PGE2 release from fibroblasts by 57% (P < 0.001 vs. baseline and saline controls, respectively). Maximal IL-1 inhibitory capacity coincided with fever and tended to disappear with declining body temperature. Normal plasma was found to inhibit TNF-alpha-induced PGE2 release by 20-35%. This inhibitory effect increased to 50-60% in plasma obtained during endotoxinemia. Maximal TNF-alpha inhibitory capacity became detectable when circulating TNF-alpha levels peaked at 120 min after the injection of endotoxin. Our data demonstrate that both IL-1 and TNF-alpha inhibitory activity can be induced experimentally by intravenous endotoxin administration to humans and that their appearance coincides with fever and circulating TNF-alpha levels.
引用
收藏
页码:R993 / R997
页数:5
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