PRO-DRUGS AS DRUG DELIVERY SYSTEMS .23. IMPROVED DERMAL DELIVERY OF 5-FLUOROURACIL THROUGH HUMAN-SKIN VIA N-ACYLOXYMETHYL PRO-DRUG DERIVATIVES

被引：56
作者：
MOLLGAARD, B [1 ]
HOELGAARD, A [1 ]
BUNDGAARD, H [1 ]
机构：
[1] ROYAL DANISH SCH PHARM, DEPT PHARMACEUT CHEM, DK-2100 COPENHAGEN, DENMARK
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1982年 / 12卷 / 2-3期
关键词：
D O I：
10.1016/0378-5173(82)90115-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：153 / 162
页数：10
相关论文
共 27 条
[1]   INVITRO ESTIMATES OF TOPICAL BIOAVAILABILITY [J].
ANDO, HY ;
HO, NFH ;
HIGUCHI, WI .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (05) :755-757
[2]   N-HYDROXYMETHYL DERIVATIVES OF NITROGEN-HETEROCYCLES AS POSSIBLE PRODRUGS .1. N-HYDROXYMETHYLATION OF URACILS [J].
BANSAL, PC ;
PITMAN, IH ;
TAM, JNS ;
MERTES, M ;
KAMINSKI, JJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (08) :850-854
[3]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .7. DERMAL DELIVERY OF CROMOGLYCIC ACID (CROMOLYN) VIA ITS PRODRUGS [J].
BODOR, N ;
ZUPAN, J ;
SELK, S .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 7 (01) :63-75
[4]   PRO-DRUGS AS DRUG DELIVERY SYSTEMS .3. ESTERS OF MALONURIC ACIDS AS NOVEL PRO-DRUG TYPES FOR BARBITURIC-ACIDS [J].
BUNDGAARD, H ;
HANSEN, AB ;
LARSEN, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1979, 3 (06) :341-353
[5]   PRO-DRUGS AS DRUG DELIVERY SYSTEMS .8. BIOREVERSIBLE DERIVATIZATION OF HYDANTOINS BY N-HYDROXYMETHYLATION [J].
BUNDGAARD, H ;
JOHANSEN, M .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 5 (01) :67-77
[6]   PENETRATION OF 5-FLUOROURACIL IN EXCISED SKIN [J].
COHEN, JL ;
STOUGHTON, RB .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1974, 62 (05) :507-509
[7]  
CULLEN SI, 1979, AM GERIAT SOC, V27, P529
[8]   SELECTIVE CYTOTOXIC EFFECT OF TOPICAL 5-FLUOROURACIL [J].
DILLAHA, CJ ;
HONEYCUTT, WM ;
BRADFORD, AC ;
JANSEN, GT .
ARCHIVES OF DERMATOLOGY, 1963, 88 (03) :247-+
[9]   GENERAL PHYSICAL MODEL FOR SIMULTANEOUS DIFFUSION AND METABOLISM IN BIOLOGICAL-MEMBRANES - COMPUTATIONAL APPROACH FOR THE STEADY-STATE CASE [J].
FOX, JL ;
YU, CD ;
HIGUCHI, WI ;
HO, NFH .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1979, 2 (01) :41-57
[10]   PERCUTANEOUS ABSORPTION - RELEVANCE OF INVITRO DATA [J].
FRANZ, TJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1975, 64 (03) :190-195
123