RAPID AND SENSITIVE GAS-CHROMATOGRAPHIC DETERMINATION OF ESTAZOLAM

被引：5

作者：

KELLY, JF ^{[1
]}

GREENBLATT, DJ ^{[1
]}

机构：

[1] TUFTS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BOSTON,MA 02111

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80082-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The triazolobenzodiazepine estazolam can be quantitated by gas chromatography with electron-capture detection. After addition of a suitable internal standard, plasma samples are extracted into toluene-isoamyl alcohol or benzene-isoamyl alcohol. The organic extract is separated, evaporated to dryness, reconstituted, and chromatographed using a 50:50 methyl-phenyl column (SP-2250). The sensitivity limit is approximately 1 ng of estazolam in a 1-ml sample. The method is suitable for clinical or experimental pharmacokinetic studies.

引用

页码：102 / 104

页数：3

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