EFFICIENT SYNTHESES OF THE MARINE ALKALOIDS MAKALUVAMINE-D AND DISCORHABDIN-C - THE 4,6,7-TRIMETHOXYINDOLE APPROACH

被引：83

作者：

SADANANDAN, EV ^{[1
]}

PILLAI, SK ^{[1
]}

LAKSHMIKANTHAM, MV ^{[1
]}

BILLIMORIA, AD ^{[1
]}

CULPEPPER, JS ^{[1
]}

CAVA, MP ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT CHEM,TUSCALOOSA,AL 35487

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 06期

关键词：

D O I：

10.1021/jo00111a043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient synthesis of the tricyclic quinonimine 20 as its trifluoroacetate 23 has been developed starting from the commercially available 2,4,5-trimethoxybenzaldehyde and proceeding via the hitherto unknown 4,6,7-trimethoxyindole (7). Quinonimine 23 is the late stage key intermediate in several previously reported syntheses of the biologically active pyrrolo[4,3,2-de]-quinoline marine alkaloids discorhabdin C (1) and makaluvamine D (3).

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页码：1800 / 1805

页数：6

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