SYNTHESIS OF HINDERED SECONDARY-AMINES VIA GRIGNARD-REAGENT ADDITION TO KETONITRONES

被引：13

作者：

SCHWARTZ, MA

HU, XF

机构：

[1] Department of Chemistry, Florida State University, Tallahassee

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 13期

关键词：

AMINE SYNTHESIS; TERT-ALKYLAMINES; DI-TERT-BUTYLAMINE; GRIGNARD ADDITION NITRONES;

D O I：

10.1016/S0040-4039(00)91707-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Grignard reagents add to ketonitrones in a nonpolar solvent to afford N,N-dialkylhydroxylamines in good yields and with little competing proton transfer. Deoxygenation of the crude hydroxylamines with carbon disulfide then completes an efficient general synthetic route to hindered sec-alkyl-tert-alkylamines and to di-tert-alkylamines.

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页码：1689 / 1692

页数：4

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