THE EFFECTS OF WEST NILE VIRUS ON MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND CLASS-II MOLECULE EXPRESSION BY LEWIS RAT SCHWANN-CELLS INVITRO

被引：32

作者：

ARGALL, KG ^{[1
]}

ARMATI, PJ ^{[1
]}

KING, NJC ^{[1
]}

DOUGLAS, MW ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT PATHOL,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 35卷 / 1-3期

关键词：

SCHWANN CELL; FLAVIVIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; AUTOIMMUNITY; FLOW CYTOMETRY;

D O I：

10.1016/0165-5728(91)90181-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of major histocompatibility complex (MHC) class I and II molecules by Lewis rat Schwann cells after infection with West Nile virus (WNV) in vitro was examined by fluorescence microscopy and flow cytometry. WNV enhanced the expression of MHC class I molecules and induced the expression of MHC class II molecules by Schwann cells. Irradiated medium from WNV-infected Schwann cell cultures upregulated class I molecule expression on dissociated Schwann cell cultures but did not induce the expression of class II molecules. This finding has implications for virally triggered autoimmune diseases of nervous tissue.

引用

页码：273 / 284

页数：12

共 43 条

[1] USE OF MICROWAVE FIXATION IN THE PREPARATION OF CELL-CULTURES FOR OBSERVATION WITH THE SCANNING ELECTRON-MICROSCOPE [J].