PLASMA-RENIN ACTIVITY, ANGIOTENSIN-II, PROSTACYCLIN AND THROMBOXANE-A2 CONCENTRATIONS IN 139 PREECLAMPTIC PATIENTS

被引：12

作者：

FURUHASHI, N ^{[1
]}

TSUJIEI, M ^{[1
]}

KIMURA, H ^{[1
]}

YAJIMA, A ^{[1
]}

KIMURA, C ^{[1
]}

IDE, Y ^{[1
]}

机构：

[1] MIYAKO HOSP, MIYAKO 027, JAPAN

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 162卷 / 03期

关键词：

PLASMA RENIN ACTIVITY; ANGIOTENSIN-II; PROSTACYCLIN; THROMBOXANE-A2; PREECLAMPSIA;

D O I：

10.1620/tjem.162.235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma renin activity, plasma concentrations of angiotensin ll (AngII), stable metabolites (6-keto-prostaglandin F1a: 6-keto-PGF1a) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1a were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1-alpha/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1-alpha and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1-alpha/TXB2.

引用

页码：235 / 241

页数：7

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