Cefepime Neurotoxicity in Patients with Renal Insufficiency

被引：13

作者：

Kim, Seon-Yu ^{[1
]}

Lee, In-Sik ^{[1
]}

Park, Seung Lee ^{[1
]}

Lee, Jongmin ^{[1
]}

机构：

[1] Konkuk Univ, Sch Med, Med Ctr, Dept Rehabil Med, 4-12 Hwayang Dong, Seoul 143729, South Korea

来源：

ANNALS OF REHABILITATION MEDICINE-ARM | 2012年 / 36卷 / 01期

关键词：

Cefepime; Neurotoxicity; Renal failure;

D O I：

10.5535/arm.2012.36.1.159

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients with renal impairment who developed neurotoxicity including lethal outcome after treatment with cefepime.

引用

页码：159 / 162

页数：4

共 10 条

[1] Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure [J].

Chatellier, D ;

Jourdain, M ;

Mangalaboyi, J ;

Ader, F ;

Chopin, C ;

Derambure, P ;

Fourrier, F .

INTENSIVE CARE MEDICINE, 2002, 28 (02) :214-217

[2] Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside [J].

Chow, KM ;

Hui, AC ;

Szeto, CC .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2005, 24 (10) :649-653

[3] Retrospective review of neurotoxicity induced by cefepime and ceftazidime [J].

Chow, KM ;

Szeto, CC ;

Hui, ACF ;

Wong, TYH ;

Li, PKT .

PHARMACOTHERAPY, 2003, 23 (03) :369-373

[4] Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function [J].

Fernandez-Torre, Jose L. .

NEUROLOGY, 2006, 67 (02) :367-367

[5] Cefepime neurotoxicity: Case report, pharmacokinetic considerations, and literature review [J].

Lam, Sum ;

Gomolin, Irving H. .

PHARMACOTHERAPY, 2006, 26 (08) :1169-1174

[6]

Neu HC., 1996, J MED, V100, P68, DOI [10.1016/s0002-9343(96) 00110-6, DOI 10.1016/s0002-9343(96)00110-6]

[7] Nonconvulsive status epilepticus associated with cefepime in a patient undergoing autologous stem cell transplantation [J].

Plensa, E ;

Gallardo, E ;

Ribera, JM ;

Batlle, M ;

Oriol, A ;

Costa, J .

BONE MARROW TRANSPLANTATION, 2004, 33 (01) :119-120

[8]

Rybak Michael, 1996, American Journal of Medicine, V100, p39S, DOI 10.1016/S0002-9343(96)00106-4

[9] The neurotoxicity and safety of treatment with cefepime in patients with renal failure [J].

Sonck, J. ;

Laureys, G. ;

Verbeelen, D. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (03) :966-970

[10] Efficacy and safety of cefepime: a systematic review and meta-analysis [J].

Yahav, Dafna ;

Paul, Mical ;

Fraser, Abigail ;

Sarid, Nadav ;

Leibovici, Leonard .

LANCET INFECTIOUS DISEASES, 2007, 7 (05) :338-348

← 1 →