Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System

被引：25

作者：

Kuro-o, Makoto ^{[1
,2
]}

机构：

[1] Jichi Med Univ, Ctr Mol Med, Div Antiaging Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan

[2] Univ Texas Southwestern Med Ctr Dallas, Div Mineral Metab, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

来源：

INTERNATIONAL JOURNAL OF NEPHROLOGY | 2018年 / 2018卷

基金：

日本学术振兴会;

关键词：

D O I：

10.1155/2018/9679841

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. It has become increasingly important to investigate mechanisms of aging unique to mammals or humans and apply the research fruits for the treatment of major age-related disorders to extend the health span. Seminal studies on the klotho mouse, a mutant exhibiting a premature aging syndrome, have identified phosphate as a proaging factor inmammals. In this review, mechanisms of phosphate-induced premature aging and potential therapeutic targets will be discussed, which may be directly applicable for developing novel strategies for the treatment of chronic kidney disease and its complications.

引用

页数：6

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