2ND-TRIMESTER ABORTION BY INTRAMUSCULAR 15-METHYL-PROSTAGLANDIN F2-ALPHA OR INTRAVAGINAL PROSTAGLANDIN E(2) SUPPOSITORIES - A RANDOMIZED TRIAL

被引：19

作者：

BORGIDA, AF ^{[1
]}

RODIS, JF ^{[1
]}

HANLON, W ^{[1
]}

CRAFFEY, A ^{[1
]}

CIARLEGLIO, L ^{[1
]}

CAMPBELL, WA ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,DIV HUMAN GENET,FARMINGTON,CT 06032

来源：

OBSTETRICS AND GYNECOLOGY | 1995年 / 85卷 / 05期

关键词：

D O I：

10.1016/0029-7844(95)00011-F

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To compare intramuscular (IM) prostaglandin 15 methyl-F-2 alpha (15M-PGF(2 alpha)) with prostaglandin E(2) (PGE(2)) vaginal suppositories for second-trimester abortion in terms of efficacy and side effects. Methods: Fifty-one women were randomized to receive either 15M-PGF(2 alpha) IM injections or PGE(2) intravaginal suppositories for second-trimester abortion. Efficacy and side effects of the two agents were analyzed by two-tailed t tests, chi(2) analysis with Fisher exact test, and survival analysis. Results: The mean times to rupture of membranes, delivery of fetus, and delivery of placenta were significantly less for women receiving PGE(2) vaginal suppositories. The cumulative abortion rate after 24 hours for the PGE(2) group was 96%, compared with 69% for the 15M-PGF(2 alpha) group. Although there were few differences in side effects, the 15M-PGF(2 alpha) group had significantly fewer headaches, fevers, and chills. Conclusion: Intravaginal PGE(2) is superior to IM 15M-PGF(2 alpha) for second-trimester abortion.

引用

页码：697 / 700

页数：4

共 12 条

[1] BERQUIST C, 1977, ACTA OBSTET GYNEC S, V66, P19
[2] INTRAFETAL PROSTAGLANDIN-F2-ALPHA ADMINISTRATION FOR MIDTRIMESTER PREGNANCY TERMINATION - A CASE-REPORT
CHRISTODOULOU, CN
KOTOULAS, IG
AGAPITOS, EB
GERMANOS, AK
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (05) : 1245 - 1246
[3] INTRAAMNIOTIC 15(S)-15-METHYL PROSTAGLANDIN-F(2-ALPHA) AND TERMINATION OF MIDDLE AND LATE 2ND-TRIMESTER PREGNANCY FOR GENETIC INDICATIONS - A CONTEMPORARY APPROACH
FERGUSON, JE
BURKETT, BJ
PINKERTON, JV
THIAGARAJAH, S
FLATHER, MM
MARTEL, MM
HOGGE, WA
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (02) : 332 - 340
[4] GRIMES DA, 1992, OBSTET GYNECOL, V80, P719
[5] GRIMES DA, 1992, TELINDES OPERATIVE G, P335
[6] COMPARISON OF INTRAVAGINAL MISOPROSTOL WITH PROSTAGLANDIN-E(2) FOR TERMINATION OF 2ND-TRIMESTER PREGNANCY
JAIN, JK
MISHELL, DR
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (05) : 290 - 293
[7] RAKHSHANI R, 1988, J REPROD MED, V33, P817
[8] ROBINS J, 1976, FERTIL STERIL, V27, P104
[9] SALAMALEKIS E, 1990, Clinical and Experimental Obstetrics and Gynecology, V17, P17
[10] Tietze C, 1986, INDUCED ABORTION WOR

← 1 2 →