SEQUENCE SIMILARITIES BETWEEN TRYPTOPHAN SYNTHASE-BETA SUBUNIT AND OTHER PYRIDOXAL-PHOSPHATE-DEPENDENT ENZYMES

被引：16
作者：
BORK, P
ROHDE, K
机构：
[1] Academy of Sciences, the GDR, Central Institute of Molecular Biology, Berlin
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 03期
关键词：
D O I：
10.1016/0006-291X(90)90830-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
On the basis of 8 tryptophan synthase β subunits (EC 4.2.1.20) consensus patterns were constructed comprising two conserved motifs. Screening of the SWISSPROT protein sequence database with these patterns indicates similarities with O-acetylserine sulfhydrolases (EC 4.2.99.8), threonine synthases (EC 4.2.99.2), L- and D-serine dehydratases (EC 4.2.1.13/ EC 4.2.1.14) and threonine dehydratases (EC 4.2.1.16). Using multiple alignment procedures the similar regions could be extended. In connection with their pyridoxal-phosphate-binding-capacity and their positions in biochemical pathways evolutionary relationships among these enzymes are discussed. © 1990.
引用
收藏
页码：1319 / 1325
页数：7
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