HIGHLY REPEATED SITES IN THE APOLIPOPROTEIN(A) GENE RECOGNIZED BY METHYLATED DNA-BINDING PROTEIN, A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN

被引：19
作者：
EHRLICH, KC
EHRLICH, M
机构：
[1] TULANE UNIV,SCH MED,DEPT BIOCHEM,NEW ORLEANS,LA 70112
[2] USDA ARS,SO REG RES CTR,NEW ORLEANS,LA 70179
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 09期
关键词：
D O I：
10.1128/MCB.10.9.4957
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.
引用
收藏
页码：4957 / 4960
页数：4
相关论文
共 50 条
[41]   AFFINITY PURIFICATION OF SEQUENCE-SPECIFIC DNA-BINDING PROTEINS [J].
KADONAGA, JT ;
TJIAN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :5889-5893
[42]   NONRADIOACTIVE ASSAY FOR SEQUENCE-SPECIFIC DNA-BINDING PROTEINS [J].
GUBLER, ML ;
ABARZUA, P .
BIOTECHNIQUES, 1995, 18 (06) :1008-1014
[43]   THE ZNF35 HUMAN ZINC FINGER GENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN [J].
PENGUE, G ;
CANNADABARTOLI, P ;
LANIA, L .
FEBS LETTERS, 1993, 321 (2-3) :233-236
[44]   A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN THAT ACTIVATES FUSHI-TARAZU SEGMENTATION GENE-EXPRESSION [J].
UEDA, H ;
SONODA, S ;
BROWN, JL ;
SCOTT, MP ;
WU, C .
GENES & DEVELOPMENT, 1990, 4 (04) :624-635
[45]   PURIFICATION OF A STAGE-SPECIFIC AND SEQUENCE-SPECIFIC DNA-BINDING PROTEIN FOR THE ARYLPHORIN GENE OF SARCOPHAGA-PEREGRINA [J].
KIM, JW ;
KOMANO, H ;
NATORI, S .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1089 (01) :21-26
[46]   THE HOX-1.3 HOMEO BOX PROTEIN IS A SEQUENCE-SPECIFIC DNA-BINDING PHOSPHOPROTEIN [J].
ODENWALD, WF ;
GARBERN, J ;
ARNHEITER, H ;
TOURNIERLASSERVE, E ;
LAZZARINI, RA .
GENES & DEVELOPMENT, 1989, 3 (02) :158-172
[47]   Synthesis and characterization of a sequence-specific DNA-binding protein that contains ruthenium polypyridyl centers [J].
Lasey, RC ;
Banerji, SS ;
Ogawa, MY .
INORGANICA CHIMICA ACTA, 2000, 300 :822-828
[48]   MINISATELLITE BINDING-PROTEIN MSBP-1 IS A SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN [J].
COLLICK, A ;
DUNN, MG ;
JEFFREYS, AJ .
NUCLEIC ACIDS RESEARCH, 1991, 19 (23) :6399-6404
[49]   Sequence-based prediction of DNA-binding sites on DNA-binding proteins [J].
Gou, Z. ;
Hwang, S. ;
Kuznetsov, B., I .
PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE, VOL 1, 2006, :268-+
[50]   Protein-Induced DNA Unwinding is An Intrinsic Feature of Certain Sequence-Specific DNA-Binding Proteins [J].
Leng, Fenfei ;
Chen, Bo .
BIOPHYSICAL JOURNAL, 2009, 96 (03) :414A-414A
12345