HIGHLY REPEATED SITES IN THE APOLIPOPROTEIN(A) GENE RECOGNIZED BY METHYLATED DNA-BINDING PROTEIN, A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN

被引：19
作者：
EHRLICH, KC
EHRLICH, M
机构：
[1] TULANE UNIV,SCH MED,DEPT BIOCHEM,NEW ORLEANS,LA 70112
[2] USDA ARS,SO REG RES CTR,NEW ORLEANS,LA 70179
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 09期
关键词：
D O I：
10.1128/MCB.10.9.4957
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.
引用
收藏
页码：4957 / 4960
页数：4
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