HIGHLY REPEATED SITES IN THE APOLIPOPROTEIN(A) GENE RECOGNIZED BY METHYLATED DNA-BINDING PROTEIN, A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN

被引：19

作者：

EHRLICH, KC

EHRLICH, M

机构：

[1] TULANE UNIV,SCH MED,DEPT BIOCHEM,NEW ORLEANS,LA 70112

[2] USDA ARS,SO REG RES CTR,NEW ORLEANS,LA 70179

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 09期

关键词：

D O I：

10.1128/MCB.10.9.4957

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.

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收藏

页码：4957 / 4960

页数：4

相关论文

共 26 条

[1] GENETIC-LINKAGE BETWEEN LIPOPROTEIN(A) PHENOTYPE AND A DNA POLYMORPHISM IN THE PLASMINOGEN GENE [J].

DRAYNA, DT ;

HEGELE, RA ;

HASS, PE ;

EMI, M ;

WU, LL ;

EATON, DL ;

LAWN, RM ;

WILLIAMS, RR ;

WHITE, RL ;

LALOUEL, JM .

GENOMICS, 1988, 3 (03) :230-236

[2] 5-METHYLCYTOSINE IN EUKARYOTIC DNA [J].

EHRLICH, M ;

WANG, RYH .

SCIENCE, 1981, 212 (4501) :1350-1357

[3] MOLECULAR-CLONING AND CHARACTERIZATION OF A FULL-LENGTH CDNA CLONE FOR HUMAN-PLASMINOGEN [J].

FORSGREN, M ;

RADEN, B ;

ISRAELSSON, M ;

LARSSON, K ;

HEDEN, LO .

FEBS LETTERS, 1987, 213 (02) :254-260

[4] TISSUE-SPECIFIC DIFFERENCES IN DNA METHYLATION IN VARIOUS MAMMALS [J].

GAMASOSA, MA ;

MIDGETT, RM ;

SLAGEL, VA ;

GITHENS, S ;

KUO, KC ;

GEHRKE, CW ;

EHRLICH, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 740 (02) :212-219

[5] THE THYROID-HORMONE RECEPTOR BINDS WITH OPPOSITE TRANSCRIPTIONAL EFFECTS TO A COMMON SEQUENCE MOTIF IN THYROID-HORMONE AND ESTROGEN RESPONSE ELEMENTS [J].

GLASS, CK ;

HOLLOWAY, JM ;

DEVARY, OV ;

ROSENFELD, MG .

CELL, 1988, 54 (03) :313-323

[6] LIPOPROTEIN(A) MODULATION OF ENDOTHELIAL-CELL SURFACE FIBRINOLYSIS AND ITS POTENTIAL ROLE IN ATHEROSCLEROSIS [J].

HAJJAR, KA ;

GAVISH, D ;

BRESLOW, JL ;

NACHMAN, RL .

NATURE, 1989, 339 (6222) :303-305

[7]

HIXSON JE, 1989, J BIOL CHEM, V264, P6013

[8] A PROTEIN FROM HUMAN PLACENTAL NUCLEI BINDS PREFERENTIALLY TO 5-METHYLCYTOSINE-RICH DNA [J].

HUANG, LH ;

WANG, R ;

GAMASOSA, MA ;

SHENOY, S ;

EHRLICH, M .

NATURE, 1984, 308 (5956) :293-295

[9] AN AP-2 ELEMENT ACTS SYNERGISTICALLY WITH THE CYCLIC AMP-INDUCIBLE AND PHORBOL ESTER-INDUCIBLE ENHANCER OF THE HUMAN PROENKEPHALIN GENE [J].

HYMAN, SE ;

COMB, M ;

PEARLBERG, J ;

GOODMAN, HM .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) :321-324

[10] TRANSCRIPTION FACTOR AP-2 MEDIATES INDUCTION BY 2 DIFFERENT SIGNAL-TRANSDUCTION PATHWAYS - PROTEIN-KINASE-C AND CAMP [J].

IMAGAWA, M ;

CHIU, R ;

KARIN, M .

CELL, 1987, 51 (02) :251-260