Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

被引：13

作者：

de Moura, C. F. G. ^{[1
]}

Ribeiro, F. A. P. ^{[1
]}

Handan, B. A. ^{[1
]}

Aguiar, O. ^{[1
]}

Oshima, C. T. F. ^{[2
]}

Ribeiro, D. A. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Biociencias, UNIFESP, Ave Ana Costa 95, BR-11060001 Santos, SP, Brazil

[2] Univ Fed Sao Paulo, Dept Pathol, UNIFESP, BR-11060001 Santos, SP, Brazil

来源：

DRUG RESEARCH | 2016年 / 66卷 / 07期

关键词：

grape juice concentrate; cadmium; rat; cytochrome C; metalloproteinases;

D O I：

10.1055/s-0035-1569452

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into 3 groups (n = 5), as follows: Control group (non-treated group, CTRL); Cadmium group (Cd) and grape juice concentrate group (Cd + GJ). Histopathological analysis revealed that liver from animals treated with grape juice concentrate improved tissue degeneration induced by cadmium intoxication. Animals intoxicated with cadmium and treated with grape juice concentrate showed higher cytochrome C gene expression in liver cells. No significant statistically differences (p > 0.05) were found to MMP 2 and 9 immuno-expression between groups. Taken together, our results demonstrate that grape juice concentrate is able to prevent tissue degeneration in rat liver as a result of increasing apoptosis.

引用

页码：339 / 344

页数：6

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