ELEVATED ALPHA(1)-ANTICHYMOTRYPSIN SERUM LEVELS IN A SUBSET OF NONDEMENTED FIRST-DEGREE RELATIVES OF ALZHEIMERS-DISEASE PATIENTS

被引：32
作者：
ALTSTIEL, LD
LAWLOR, B
MOHS, R
SCHMEIDLER, J
DALTON, A
MEHTA, P
DAVIS, K
机构：
[1] BRONX VET ADM MED CTR,PSYCHIAT SERV,NEW YORK,NY
[2] ST JAMES HOSP,DEPT PSYCHIAT TCD,DUBLIN 8,IRELAND
[3] NEW YORK STATE INST BASIC RES DEV DISABIL,STATEN ISL,NY 10314
来源：
DEMENTIA | 1995年 / 6卷 / 01期
关键词：
ALZHEIMERS-DISEASE; FIRST-DEGREE RELATIVE; ACUTE PHASE REACTANT; ALPHA(1)-ANTICHYMOTRYPSIN;
D O I：
10.1159/000106917
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A portion of Alzheimer's disease (AD) patients have elevated serum levels of the acute phase reactant a(1)-antichymotrypsin (A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down's syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology.
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页码：17 / 20
页数：4
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