ACTIVITY OF PENCICLOVIR AGAINST EPSTEIN-BARR-VIRUS

被引：30
作者：
BACON, TH
BOYD, MR
机构：
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 07期
关键词：
D O I：
10.1128/AAC.39.7.1599
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Penciclovir inhibited the productive replication cycle of Epstein-Barr virus (EBV) in assays measuring infectious virus production, viral antigen expression, and viral DNA synthesis. In the test measuring inhibition of EBV DNA synthesis, 50% effective concentrations of penciclovir and acyclovir were 2.3 +/- 0.8 and 2.2 +/- 0.6 mu g/ml, respectively. The 50% cell growth inhibitory concentration of penciclovir was >100 mu g/ml for both P(3)HR-1 and Raji cells. Penciclovir is a selective inhibitor of EBV in cell culture.
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页码：1599 / 1602
页数：4
相关论文
共 34 条
[1]   EFFECT OF ACYCLOVIR ON INFECTIOUS-MONONUCLEOSIS - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY [J].
ANDERSSON, J ;
BRITTON, S ;
ERNBERG, I ;
ANDERSSON, U ;
HENLE, W ;
SKOLDENBERG, B ;
TISELL, A .
JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (02) :283-290
[2]   MOLECULAR-CLONING OF THE COMPLETE EPSTEIN-BARR VIRUS GENOME AS A SET OF OVERLAPPING RESTRICTION ENDONUCLEASE FRAGMENTS [J].
ARRAND, JR ;
RYMO, L ;
WALSH, JE ;
BJORCK, E ;
LINDAHL, T ;
GRIFFIN, BE .
NUCLEIC ACIDS RESEARCH, 1981, 9 (13) :2999-3014
[3]  
Bacon T. H., 1993, Antiviral Research, V20, P109
[4]   AN OVERVIEW OF THE FURTHER EVALUATION OF PENCICLOVIR AGAINST HERPES-SIMPLEX VIRUS AND VARICELLA-ZOSTER VIRUS IN CELL-CULTURE HIGHLIGHTING CONTRASTS WITH ACYCLOVIR [J].
BACON, TH ;
SCHINAZI, RF .
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1993, 4 :25-36
[5]   PENCICLOVIR - A REVIEW OF ITS SPECTRUM OF ACTIVITY, SELECTIVITY, AND CROSS-RESISTANCE PATTERN [J].
BOYD, MR ;
SAFRIN, S ;
KERN, ER .
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1993, 4 :3-11
[6]   ANTIHERPESVIRUS ACTIVITY OF 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE (BRL-39123) IN CELL-CULTURE [J].
BOYD, MR ;
BACON, TH ;
SUTTON, D ;
COLE, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (08) :1238-1242
[7]   ANTIHERPESVIRUS ACTIVITY OF 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL) GUANINE (BRL-39123) IN ANIMALS [J].
BOYD, MR ;
BACON, TH ;
SUTTON, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (03) :358-363
[8]   INTERACTION OF EPSTEIN-BARR VIRUS-DNA POLYMERASE AND 5'-TRIPHOSPHATES OF SEVERAL ANTIVIRAL NUCLEOSIDE ANALOGS [J].
CHIOU, JF ;
CHENG, YC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (03) :416-418
[9]   PHOSPHORYLATION OF ACYCLOVIR [9-(2-HYDROXYETHOXYMETHYL)GUANINE] IN EPSTEIN-BARR VIRUS-INFECTED LYMPHOBLASTOID CELL-LINES [J].
COLBY, BM ;
FURMAN, PA ;
SHAW, JE ;
ELION, GB ;
PAGANO, JS .
JOURNAL OF VIROLOGY, 1981, 38 (02) :606-611
[10]   EFFECT OF ACYCLOVIR [9-(2-HYDROXYETHOXYMETHYL)GUANINE] ON EPSTEIN-BARR VIRUS-DNA REPLICATION [J].
COLBY, BM ;
SHAW, JE ;
ELION, GB ;
PAGANO, JS .
JOURNAL OF VIROLOGY, 1980, 34 (02) :560-568
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