EFFECT OF THE VALINE THREONINE CONSTRAINT ON THE DYNAMICS OF THE PROLINE HELIX - A MOLECULAR-DYNAMICS STUDY

被引:0
作者
SHOBANA, S [1 ]
NADIG, G [1 ]
VISHVESHWARA, S [1 ]
机构
[1] INDIAN INST SCI, MOLEC BIOPHYS UNIT, BANGALORE 560012, KARNATAKA, INDIA
来源
PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES | 1994年 / 106卷 / 02期
关键词
PROLINE HELIX; VALINE-THREONINE CONSTRAINT; MOLECULAR DYNAMICS;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Proline residues in helices play an important role in the structure of proteins. The proline residue introduces a kink in the helix which varies from about 5-degrees to 50-degrees. The presence of other residues such as threonine or valine near the proline region can influence the flexibility exhibited by the kinked helix, which can have an important biological role. In the present paper, the constraint introduced by threonine and valine on a proline helix is investigated by molecular dynamics studies. The systems considered am (1) a poly-alanine helix with threonine-proline residues (TP) and (2) a poly-alanine helix with valine-threonine-proline residues (VTP), in the middle. Molecular dynamics simulations are carried out on these two systems for 500 ps. The results are analyzed in terms of structural transitions, bend-related parameters and sidechain orientations.
引用
收藏
页码:579 / 589
页数:11
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