ASSOCIATION OF MS PI PHENOTYPE WITH AIRWAY HYPERRESPONSIVENESS

被引：35
作者：
TOWNLEY, RG
SOUTHARD, JG
RADFORD, P
HOPP, RJ
BEWTRA, AK
FORD, L
机构：
[1] Creighton University, School of Medicine, Omaha, NE 68178
来源：
CHEST | 1990年 / 98卷 / 03期
关键词：
D O I：
10.1378/chest.98.3.594
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.
引用
收藏
页码：594 / 599
页数：6
相关论文
共 30 条
[1]  
ARNAUD P, 1976, T ASSOC AM PHYSICIAN, V84, P205
[2]  
BRANTLY M, 1988, AM J MED, V84, P13
[3]   CLINICAL-FEATURES AND HISTORY OF THE DESTRUCTIVE LUNG-DISEASE ASSOCIATED WITH ALPHA-1-ANTITRYPSIN DEFICIENCY OF ADULTS WITH PULMONARY SYMPTOMS [J].
BRANTLY, ML ;
PAUL, LD ;
MILLER, BH ;
FALK, RT ;
WU, M ;
CRYSTAL, RG .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (02) :327-336
[4]  
BUIST AS, 1979, AM REV RESPIR DIS, V120, P759
[5]  
COLP C R, 1988, Chest, V94, p63S
[6]  
COOPER DM, 1974, AM REV RESPIR DIS, V110, P708
[7]   THE ALPHA-1-ANTITRYPSIN GENE AND ITS MUTATIONS - CLINICAL CONSEQUENCES AND STRATEGIES FOR THERAPY [J].
CRYSTAL, RG ;
BRANTLY, ML ;
HUBBARD, RC ;
CURIEL, DT ;
STATES, DJ ;
HOLMES, MD .
CHEST, 1989, 95 (01) :196-208
[8]   CIGARETTE-SMOKE INDUCES BRONCHOCONSTRICTOR HYPERRESPONSIVENESS TO SUBSTANCE-P AND INACTIVATES AIRWAY NEUTRAL ENDOPEPTIDASE IN THE GUINEA-PIG - POSSIBLE ROLE OF FREE-RADICALS [J].
DUSSER, DJ ;
DJOKIC, TD ;
BORSON, DB ;
NADEL, JA .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (03) :900-906
[9]  
ERIKSSON S, 1965, ACTA MED SCAND S432, V177, P421
[10]  
FAGERHOL MAGNE K., 1968, SER HAEMATOL, V1, P153
123