MACROPHAGE ACTIVATION FOR TUMOR-CYTOTOXICITY - GENETIC-VARIATION IN MACROPHAGE TUMORICIDAL CAPACITY AMONG MOUSE STRAINS

被引：58
作者：
BORASCHI, D
MELTZER, MS
机构：
来源：
CELLULAR IMMUNOLOGY | 1979年 / 45卷 / 01期
关键词：
D O I：
10.1016/0008-8749(79)90375-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Development of activated tumoricidal macrophages following Mycobacterium bovis, strain BCG infection in vivo or lymphokine treatment in vitro was examined with more than 20 mouse strains. Peritoneal macrophages from 8 of 22 strains failed to develop tumoricidal capacity by 7 days after i.p. BCG infection. Macrophages from 6 of 6 in vivo nonresponder strains failed develop tumoricidal capacity after in vitro treatment with lymphokines. Identification of nonresponder mouse strains should provide a useful resource for analysis of intermediary reactions in macrophage activation.
引用
收藏
页码：188 / 194
页数：7
相关论文
共 14 条
[1]  
ALLEN EM, 1977, J IMMUNOL, V119, P343
[2]  
ARANJO FG, 1976, INFECT IMMUN, V13, P1528
[3]  
CIVIL RH, 1978, J IMMUNOL, V120, P1070
[4]   HIGH SUSCEPTIBILITY OF STRAIN A MICE TO ENDOTOXIN AND ENDOTOXIN-RED BLOOD CELL MIXTURES [J].
HEPPNER, G ;
WEISS, DW .
JOURNAL OF BACTERIOLOGY, 1965, 90 (03) :696-&
[5]  
HIBBS JB, 1976, MACROPHAGE NEOPLASIA
[6]  
LITTLE CC, 1943, GENETICS MOUSE
[7]  
MEDINA S, 1975, J IMMUNOL, V114, P720
[8]   HISTOCOMPATIBILITY-LINKED GENETIC-CONTROL OF DISEASE SUSCEPTIBILITY - MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION [J].
OLDSTONE, MB ;
DIXON, FJ ;
MITCHELL, GF ;
MCDEVITT, HO .
JOURNAL OF EXPERIMENTAL MEDICINE, 1973, 137 (05) :1201-1212
[9]  
PECK AB, 1977, IMMUNOL REV, V35, P146, DOI 10.1111/j.1600-065X.1977.tb00239.x
[10]  
RUCO LP, 1978, J IMMUNOL, V120, P1054
12